Ca2+/Na+ Signaling in PDAC(pancreatic ductal adenocarcinoma) microenvironment
Project : Postdoctoral position is currently available in the Inserm U1003, Laboratory of Cell Physiology, University of Lille to study the molecular mechanisms underlying calcium/sodium signaling in PDAC microenvironmental niche and to determine their contribution to cell dysfunction, and disease. The main goal of the project is to decipher the effect of microenvironmental triggers (mechanical stress, hypoxia, secretome) on ion channels regulating the intracellular Na+ and Ca2+ homeostasis in pancreatic cancer cells and stroma cells such as stellate cells.
Ongoing studies in the laboratory address the role of plasma membrane calcium entry mechanisms, involving Orai1/STIM1 and TRP channels, as well as intracellular calcium channels, such as IP3Rs in the endoplasmic reticulum, as well as mitochondrial calcium uptake in cancer progression. The lab offers a highly-collaborative training environment for young scientists, with cutting-edge resources, patch-clamp set-ups, microscopes and expertise.
Candidate’s profile: Applicants should have a strong background in cell physiology and biochemistry and good oral and written communication skills. Expertise in electrophysiology, cellular imaging, molecular biology, and various biochemistry techniques are required. Additional experiences in calcium signaling and working with animal models are highly desirable.
Application : If interested, please send an email with details of research experience and technical expertise, together with a complete CV and the names and contact information of three references to Pr. Natalia Prevarskaya (natacha.prevarskaya@univ-lille.fr).