Team of María Cecilia Angulo Neuron-oligodendroglia interactions in myelination and myelin repair Insitute of Psychiatry and Neuroscience of Paris (IPNP) INSERM U1266, Paris, France
Profile : We are looking for a postdoctoral fellow with expertise in electrophysiology, optogenetics, in vivo recordings and/or behavior and who has a special interest in regeneration. The post-doc candidate will integrate our team located in the new Institut of Psychiatry and Neuroscience of Paris (IPNP) inside Sainte-Anne Hospital, a highly stimulating environment.
Project : When myelination is impaired or myelin is destroyed in the CNS, cognitive, motor and sensory functions are compromised. Despite the low regeneration capacity of the CNS, a spontaneous production of newly formed oligodendrocytes and a partial myelin repair can occur in response to a demyelinating injury. We recently showed that a moderate neuronal activity in vivo improves myelin repair by increasing both the density of OLs and myelin production in demyelinated lesions, inducing a remarkable functional recovery (Ortiz et al., 2019). The present project aims to determine the mechanisms allowing neuronal activity to improve myelin repair and, in turn, action potential conduction.
Lab : Recent relevant publications of the team:
Orduz D et al., (2019) Nat Commun 10:4249 Ortiz FC et al. (2019) JCI Insight 4(9):e123434 Balia M et al. (2017) Glia 65(11):1821-1832 Wake H et al. (2015) Nat Commun 6:7844. Orduz D et al. (2015) eLife 4:e06953
The position will be for 2 years
Starting date: as soon as possible
Application : Interested candidates should send their CV, a motivation letter including research interests and names of 2 referees to: firstname.lastname@example.org