|Description||For an ambitious project we are looking for 2 PhD students, a post-doctoral fellow and a technician|
In a joint research program of Verhaagen and Huitinga, funded by the Start2Cure Foundation, we will develop a regenerative therapy to restore function in MS. Our approach is to apply cutting edge gene therapy technology to deliver therapeutic targets to the CNS. Targets will be identified in brain tissue of MS brain donors of the Netherlands Brain Bank (NBB) that exhibited a high intrinsic capability to repair MS-related damage. Together with Start2Cure, we will push for recovery of brain damage in MS by shortening the path from science to clinical application. For this ambitious project we are looking for 2 PhD students, a post-doctoral fellow and a technician. A second post-doctoral fellow has already joined the team.
POST-DOCTORAL FELLOW, 1.0 FTE, 4 YEARS
The post-doctoral fellow will perform transcriptomics and bioinformatics studies to identify targets in brain tissue of MS donors and will validate the efficacy of these targets in vitro using iPSC-derived human oligodendrocytes and in vivo in animal models for MS. You will supervise PhD student 1.
Desired skills: Knowledge of MS pathology, experience with human brain tissue, transcriptomics, analysis of large data sets and bioinformatics. Experience with MS animal models, cell isolation and cell culture is appreciated.
PHD STUDENT 1, 1.0 FTE, 4 YEARS
This Ph.D. student will execute the transcriptomics analyses of MS brain tissues and will, together with the second PhD student, test the efficacy of targets in the MS animal models.
Desired skills: This PhD student has completed a Master in Neuroscience or in Biomedical Science or a related field. Experience with animal research is required. Experience with gene expression profiling, bioinformatics, human brain pathology, neuroimmunology and immune histochemistry would be important assets.
PHD STUDENT 2, 1.0 FTE, 4 YEARS
PhD student 2 will develop non-invasive viral vectors that target CNS cells, including astrocytes, oligodendrocyte and microglia. These vectors will be used to express the targets, identified in human brain tissue, in MS animal models to study their effects on brain repair at the anatomical and functional level.
Desired skills: This PhD student has completed a Master in Neuroscience or in Biotechnology or a related field. Experience with molecular biological techniques, in particular viral vector and in vivo imaging technology and experimental animal research are requirements for this position.
TECHNICIAN, 1.0 FTE, 4 YEARS
The technician will be responsible for the development of non-invasive viral vectors, setting up and running the MS animal models and the functional testing in these models.
Desired skills: The technician has a bachelor in applied science (BAS) degree in zoology (HLO level; article 12). Experience with experimental animal research, preferably the MS models and/or behavioral testing. Experience with histological techniques would be an asset.
We are looking for team players with a specific interest in MS and brain repair, with excellent communication skills and an ability to work and troubleshoot independently and collaboratively.
The salary is in accordance with the regulations for academic personnel, and will range from €2395,- up to a maximum of €3061,- per month before tax, for PhD students, from €3217,- up to 3886,- gross per month for the post doc and from €2329,- up to 3144,- gross per month for the technician, resp. (excluding 8% holiday and 8,3% end of year allowance) based on a full-time appointment, and depending on expertise and previous experience. The gross monthly salaries are in accordance with the Collective Labour Agreement (CAO) for Dutch Universities. We offer travel expenses, paid parental leave, flexible working hours, 30 days paid leave per year and help by finding a house.
APPLICATION AND DEADLINE
Applicants are requested to write a letter in which they motivate their application, accompanied by a curriculum vitae and one or two references. Applications should be sent before 3 1 January 2021 to the Netherlands Institute for Neuroscience, attn. of HR department (firstname.lastname@example.org), with references “PhD student 1 or 2, or Post Doc or technician of S2C project Repair MS”. Evaluation of candidates will begin immediately and will continue until the vacancy is filled.